KO-Validated BCL2 Like 11 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KO-Validated BCL2 Like 11 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:BCL2L11; BCL2 Like 11; BIM; BOD; BCL2-Like 11 (Apoptosis Facilitator); Bcl-2-Like Protein 11; BimEL; BimL; BimS; Bcl-2 Interacting Mediator Of Cell Death; Bcl2-Interacting Mediator Of Cell Death; Bcl-2-Related Ovarian Death Agonist; Bcl-2 Interacting Protein Bim; Bcl2-L-11; BAM Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013] Research Area: Cell Biology,Neuroscience,Immunology,Signal Transduction,Cancer,Metabolism