KO-Validated Catenin Beta 1 Mouse Monoclonal Antibody

Description

EnkiLife offers the KO-Validated Catenin Beta 1 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:CTNNB1; Catenin Beta 1; Beta-Catenin; Armadillo; CTNNB; Catenin (Cadherin-Associated Protein), Beta 1, 88kDa; Catenin Beta-1; Catenin (Cadherin-Associated Protein), Beta 1 (88kD); Catenin (Cadherin-Associated Protein), Beta 1; NEDSDV; MRD19; EVR7 Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] Research Area: Signal Transduction,Neuroscience,Stem Cells,Cancer,Cardiovascular