KO-Validated CD274 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KO-Validated CD274 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:CD274; CD274 Molecule; PD-L1; B7H1; PDL1; Programmed Cell Death 1 Ligand 1; CD274 Antigen; B7 Homolog 1; PDCD1LG1; B7-H1; B7-H; PDCD1 Ligand 1; PDCD1L1; HPD-L1; Programmed Death Ligand 1 Background: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Research Area: Immunology,Cancer