KO-Validated Chromobox 3 Mouse Monoclonal Antibody

Description

EnkiLife offers the KO-Validated Chromobox 3 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500; IHC-P 1:250-1:500 Alternative Names of Immunogen:CBX3; Chromobox 3; HP1Hs-Gamma; HP1gamma; Heterochromatin Protein 1 Homolog Gamma; Chromobox Protein Homolog 3; Modifier 2 Protein; HECH; Chromobox Homolog 3 (HP1 Gamma Homolog, Drosophila); Chromobox Homolog 3 (Drosophila HP1 Gamma); Heterochromatin Protein HP1 Gamma; HP1 Gamma Homolog (Drosophila); Heterochromatin-Like Protein 1; Chromobox Homolog 3; HP1 Gamma Homolog; HP1-GAMMA; HP1 Gamma Background: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011] Research Area: Epigenetics and Nuclear Signaling