KO-Validated PCSK9 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KO-Validated PCSK9 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:PCSK9; Proprotein Convertase Subtilisin/Kexin Type 9; NARC-1; FH3; Subtilisin/Kexin-Like Protease PC9; HCHOLA3; NARC1; PC9; Convertase Subtilisin/Kexin Type 9 Preproprotein; Hypercholesterolemia, Autosomal Dominant 3; Neural Apoptosis Regulated Convertase 1; Neural Apoptosis-Regulated Convertase 1; Proprotein Convertase 9; EC 3.4.21.111; EC 3.4.21.-; EC 3.4.21; LDLCQ1; FHCL3 Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Research Area: Signal Transduction,Cardiovascular,Stem Cells,Cell Biology,Metabolism,Neuroscience