KO-Validated Phospho-Smad3 (S423 + S425) Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KO-Validated Phospho-Smad3 (S423 + S425) Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:SMAD3; SMAD Family Member 3; JV15-2; HsT17436; MADH3; Mothers Against Decapentaplegic Homolog 3; Mothers Against DPP Homolog 3; MAD Homolog 3; HMAD-3; HSMAD3; Mad3; MAD, Mothers Against Decapentaplegic Homolog 3 (Drosophila); SMAD, Mothers Against DPP Homolog 3 (Drosophila); MAD, Mothers Against Decapentaplegic Homolog 3; SMAD, Mothers Against DPP Homolog 3; SMA- And MAD-Related Protein 3; Mad Protein Homolog; Mad Homolog JV15-2; HSPC193; SMAD 3; LDS1C; Smad3; LDS3 Background: The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022] Research Area: Signal Transduction,Epigenetics and Nuclear Signaling,Stem Cells,Cancer,Metabolism