KOR agonist 4

Description

KOR agonist 4 compound 39 is an agonist of Kappa Opioid Receptor. KOR agonist 4 is an activator of G-protein signaling. KOR agonist 4 binds with GTP?S with an EC50 of 14 nM and with an Emax of 83 %. KOR agonist 4 demonstrates moderate to high intrinsic clearance in human hepatocytes. KOR agonist 4 exhibits 60- and 810-fold selectivities versus the related mu MOR and delta DOR opioid receptors. KOR agonist 4 is potential for central nervous system CNS disorders research.