GENERAL CATALOGUE
KPLH1130
HY-128578 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-128578
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medchemexpress.com/kplh1130.htmlCatalog No: HY-128578
CAS No: 906669-07-6
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
KPLH1130 is a pyruvate dehydrogenase kinase PDK inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers HIF-1?, iNOS and nitric oxide NO production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate OCR induced by inflammatory stimuli LPS HY-D1056 + IFN-? in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions.
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