GENERAL CATALOGUE
KRAS inhibitor-9
HY-137497 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-137497
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medchemexpress.com/kras-inhibitor-9.htmlCatalog No: HY-137497
CAS No: 300809-71-6
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
KRAS inhibitor-9, a potent KRAS inhibitor Kd=92 ?M , blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells.
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