GENERAL CATALOGUE
KRASG12C IN-15
HY-173047 · 50 mg
MedChemExpress · Cat: HY-173047
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medchemexpress.com/krasg12c-in-15.html
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Catalog No: HY-173047
CAS No: 2768868-14-8
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
KRASG12C IN-15 Compound 21 is the orally active inhibitor for KRASG12C, and inhibits SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. KRASG12C IN-15 inhibits the phosphorylation of ERK with IC50 of 0.051 ?M. KRASG12C IN-15 inhibits the cell viability of KRASG12C mutated MIA PaCa-2 with IC50 of 0.023 ?M. KRASG12C IN-15 exhibits antitumor effect in MIA PaCa-2 xenograft mouse models.
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