

HY-139178 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-139178
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Manufacturer product page
medchemexpress.com/kva-d-88.html
Description
KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 has the ability to inhibit cocaine-induced hyperlocomotor activity and sensitization. KVA-D-88 selectively inhibits PDE4B and reduces cAMP degradation, thereby modulating neuroadaptive responses. KVA-D-88 can be used in the study of cocaine addiction.







