GENERAL CATALOGUE
KY-1044
HY-P99431 · 1 mg
MedChemExpress · Cat: HY-P99431
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medchemexpress.com/ky-1044.htmlCatalog No: HY-P99431
CAS No: 2489390-15-8
Category: Immunology Inflammation
Pack Size: 1 mg
Brand: MedChemExpress
Description
KY-1044 Alomfilimab; SAR 445256 is a fully human IgG1 antibody targeting inducible costimulatory receptor ICOS . KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity ADCC through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells through FcgR-dependent clustering . KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response.
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