GENERAL CATALOGUE
Kylo-0603
HY-172661 · 50 mg
MedChemExpress · Cat: HY-172661
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Catalog No: HY-172661
CAS No: 2661053-09-2
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
KYLO-0603 is an orally active, selective THR-? agonist EC50: 31.07 nM . KYLO-0603 has significant activity in lowering serum cholesterol and low-density lipoprotein cholesterol. KYLO-0603 upregulates the expression of THR-regulated genes including iodothyronine deiodinase 1 Dio1 , malic enzyme 1 Me1 , and thyroid hormone response Thrsp gene and inhibits the expression of inflammatory and fibrotic genes low-density lipoprotein receptor LDL-R gene by activating THR-? receptors. KYLO-0603 can be used to treat metabolic dysfunction-associated steatohepatitis MASH and liver fibrosis research.
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