GENERAL CATALOGUE
L-685458
HY-19369 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-19369
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Catalog No: HY-19369
CAS No: 292632-98-5
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
L-685458 is a potent transition state analog TSA ?-secretase inhibitor GSI . L-685458 inhibits amyloid ?-protein precursor ?-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits ?-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimerAAasAasAas disease AD and cancers.
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