GENERAL CATALOGUE
L6H21
HY-W082785A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-W082785A
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medchemexpress.com/l6h21.htmlCatalog No: HY-W082785A
CAS No: 24533-47-9
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
L6H21, a Chalcone HY-121054 derivative, is an orally active, potent and specific myeloid differentiation 2 MD-2 inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 ?M, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-? and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 ?M, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research.
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