GENERAL CATALOGUE
L748337
HY-103211 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-103211
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Catalog No: HY-103211
CAS No: 244192-94-7
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
L748337 is a potent ?3-adrenergic receptor antagonist and displays selectivity over ?1 and ?2 receptors. The Ki values of L748337 for ?3-, ?2- and ?1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease NAFLD , and cardiovascular related diseases.
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