Lamin A/C Rabbit Monoclonal Antibody

Description

EnkiLife offers the Lamin A/C Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ICC/IF,IP application. Alternative Names of Immunogen: LMNA; LMN1; Prelamin-A/C. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,IP 1:20-1:50 Background: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. Research Area: Tags & Cell Markers