(-)-Latifolin

Description

- -Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. - -Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma OSCC , and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. - -Latifolin suppresses autophagic-related proteins and autophagosome formation. - -Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins RIP1, RIP3, and MLKL . - -Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities.