LC-04-045

Description

LC-04-045 is a NEK7 NIMA-related kinase 7 molecular glue degrader MGD . LC-04-045 demonstrates potent activity of NEK7 degradation with a DC50 half-maximal degradation of 7 nM and a Dmax maximum degradation of 90 % in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome. LC-04-045 degrades NEK7 mediated by the ubiquitin-proteasome system UPS and relies on the glycine 57 G57 -containing degron motif in NEK7. LC-04-045 effectively inhibits secretion of IL-1? and IL-18 with IC50s of 33.03 nM and 32.99 nM, respectively. LC-04-045 is potential for inflammatory diseases research.