GENERAL CATALOGUE
LC-2
HY-137516 · 1 mg
MedChemExpress · Cat: HY-137516
₹260 – ₹380 approx.This price excludes freight and taxes. Please RFQ to get the final price.
Reach 3+ verified distributors
Manufacturer product page
medchemexpress.com/protac-krasg12c-degrader-lc-2.html
Sponsored
Catalog No: HY-137516
CAS No: 2502156-03-6
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 ?M. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines.
More from MedChemExpress
GPR120 Agonist 1
HY-108711
GPCR G Protein
AG-045572
HY-107534
GPCR G Protein
Pamabrom
HY-17391
GPCR G Protein
ZD-7114
HY-101320
GPCR G Protein
Vasopressin Dimer (anti-parallel) (TFA)
HY-P5214
GPCR G Protein
Zimeldine-d6
HY-118835S
GPCR G Protein
ZM241385 (Standard)
HY-19532R
GPCR G Protein
(5S,6S)-DiHETE
HY-130138
GPCR G Protein