GENERAL CATALOGUE
LC-SF-14
HY-172916 · 50 mg
MedChemExpress · Cat: HY-172916
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medchemexpress.com/lc-sf-14.html
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Catalog No: HY-172916
Category: MAPK ERK Pathway
Pack Size: 50 mg
Brand: MedChemExpress
Description
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR IC50 values are 71.6 and 8.9 nM, respectively . LC-SF-14 inhibits FGFR2-FRS2?-SHP2-MAPK signaling and ERK phosphorylation. LC-SF-14 inhibits the proliferation of KATOIII cancer cells IC50: 9.2 nM . LC-SF-14 has antitumor activity in the SNU-16 xenograft mouse model. LC-SF-14 can be used in FGFR2-driven gastric cancer research.
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