LC3B recruiter 2

Description

LC3B recruiter 2 34R is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system ATTEC, Autophagy-Tethering Compounds , which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 HY-10008 through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex with inhibitory effects on both . Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity.