LCC-12 formate

Description

LCC-12 formate is a copper II chelator and a derivative of the biguanide metformin HY-B0627 . LCC-12 formate reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+. LCC-12 formate reduces IL-1?, IL-2, IL-6, IL-8, and TNF-? levels, as well as JAK2, STAT2, and IL-1 receptor-associated kinase 4 IRAK4 levels in primary human cytokine-activated monocyte-derived macrophages MDMs . LCC-12 formate reduces the number of CD80+ and CD86+ cytokine-activated MDMs. LCC-12 LCC-12 formate improves survival in a mouse model of sepsis induced by LPS or cecal ligation and puncture.