GENERAL CATALOGUE
LCL768
HY-176568 · 50 mg
MedChemExpress · Cat: HY-176568
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Catalog No: HY-176568
Category: Autophagy
Pack Size: 50 mg
Brand: MedChemExpress
Description
LCL768 is a ceramide analog. LCL768 attenuates PARKIN succination to promote PARKIN activation and mitophagy. LCL768 induces CerS1-mediated endogenous C18-ceramide accumulation in mitochondria to mediate mitophagy, which is dependent on DRP1 activation via nitrosylation at C644. LCL768 alters mitochondrial metabolism, resulting in fumarate depletion and leading to tumor suppression. LCL768 improves sensorimotor defects in neurodegenerative diseases like ALS.
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