LDHA-IN-8

Description

LDHA-IN-8 Compound 6 is a lactate dehydrogenase LDHA inhibitor. LDHA-IN-8 inhibits LDHA catalysis of pyruvate in a dose-dependent manner EC50 value of 14.54 ?M , reduces intracellular lactate levels, and increases intracellular reactive oxygen species ROS levels, thereby inhibiting the proliferation of pancreatic cancer cells and lung cancer cells. LDHA-IN-8 holds promise for research in the field of LDHA-related antitumor therapies.