LexA DNA Binding Region Rabbit Polyclonal Antibody

Description

EnkiLife offers the LexA DNA Binding Region Rabbit Polyclonal Antibody. This antibody reacts with Cyanobacteria species and is suitable for WB application. Alternative Names of Immunogen: lexa dna binding region. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000 Background: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment. Research Area: Microbiology