Licoricidin

Description

Licoricidin LCD is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin LCD inhibit SW480 cells IC50=7.2 ?M by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin LCD inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma OS cells by inactivation of the Akt and NF-?B pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations.