GENERAL CATALOGUE
Lifirafenib hydrochloride
HY-18957C · 50 mg
MedChemExpress · Cat: HY-18957C
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Manufacturer product page
medchemexpress.com/lifirafenib-hydrochloride.htmlCatalog No: HY-18957C
CAS No: 2025320-97-0
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
Lifirafenib hydrochloride BGB-283 hydrochloride is a novel, reversible B-RAFV600E inhibitor with antitumor activity. Lifirafenib has shown potent antitumor activity against solid tumors with B-RAFV600E mutations, such as melanoma, thyroid cancer, and low-grade serous ovarian cancer. Lifirafenib exhibits selective cytotoxicity in vitro, preferentially inhibiting the proliferation of cancer cells with B-RAFV600E and EGFR mutations/amplification. Lifirafenib can achieve dose-dependent inhibition of tumor growth in animal models, accompanied by partial and complete tumor shrinkage.
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