Lin28B Rabbit Monoclonal Antibody

Description

EnkiLife offers the Lin28B Rabbit Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,ICC/IF,FC,IP application. Alternative Names of Immunogen: CSDD2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50 Background: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]