GENERAL CATALOGUE
Lipid 114
HY-171900 · 50 mg
MedChemExpress · Cat: HY-171900
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Manufacturer product page
medchemexpress.com/lipid-114.htmlCatalog No: HY-171900
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. Lipid 114 can be used to generate lipid nanoparticles LNP to deliver siRNA in vitro as well as in vivo. Lipid 114 LNPs encapsulating siRNA that targets IL-1? can reduce IL-1? expression in macrophages. Lipid 114 LNPs encapsulating siRNA that targets IL-1? also reduces hepatic and renal expression of IL-1?, as well as decreasing hepatic inflammation in mouse model with LPS-induced acute liver failure.
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