GENERAL CATALOGUE
LLC0424
HY-161574 · 1 mg
MedChemExpress · Cat: HY-161574
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Catalog No: HY-161574
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
LLC0424 is a potent and selective cereblon-based PROTAC nuclear receptor-binding SET domain-containing 2 NSD2 degrader. LLC0424 effectively degraded NSD2 with a DC50 of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. Blue: CRBN ligand HY-14658 , Black: linker HY-40002 ; Pink: NSD2 inhibitor HY-161575 .
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