GENERAL CATALOGUE
LML134
HY-128656 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-128656
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Catalog No: HY-128656
CAS No: 1542135-76-1
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
LML134 compound 18b is an orally active and high selective Histamine 3 receptor H3R inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders.
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