Lobaric acid

Description

Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals IC50=97.9 ?M and inhibits cancer cell proliferation EC50 of 15.2-63.9 ?g/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines . Lobaric acid inhibits protein tyrosine phosphatase 1B PTP1B; IC50=0.87 ?M for human recombinant enzyme and 12 S -HETE produced by 12 S -lipoxygenase IC50=28.5 ?M . Lobaric acid 250 ?M also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus TMV .