GENERAL CATALOGUE
LOC14
HY-100432 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-100432
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Manufacturer product page
medchemexpress.com/loc14.htmlCatalog No: HY-100432
CAS No: 877963-94-5
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
LOC14 is a potent Protein disulfide isomerase PDI inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding. LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization maturation of HA in lung epithelial cells.