

HY-12390 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-12390
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medchemexpress.com/lofepramine.html
Description
Lofepramine Lopramine is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline NA HY-13715 and 5-hydroxytryptamine 5-HT with IC50s of 2.7 ?M and 11 ?M, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .







