GENERAL CATALOGUE
Lometrexol disodium
HY-14521A · 1 mg
MedChemExpress · Cat: HY-14521A
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medchemexpress.com/lometrexol-disodium.htmlCatalog No: HY-14521A
CAS No: 120408-07-3
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
Lometrexol DDATHF disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase GARFT but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 hSHMT1/2 inhibitor.
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