GENERAL CATALOGUE
Lometrexol hydrate
HY-14521B · 1 mg
MedChemExpress · Cat: HY-14521B
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Catalog No: HY-14521B
CAS No: 1435784-14-7
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
Lometrexol DDATHF hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase GARFT but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 hSHMT1/2 inhibitor.
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