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Lorlatinib
GENERAL CATALOGUE

Lorlatinib

HY-12215 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-12215

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Manufacturer product page

medchemexpress.com/PF-06463922.html
Catalog No: HY-12215
CAS No: 1454846-35-5
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

Lorlatinib PF-06463922 is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of 0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM ALKL1196 , 14-80 nM ALKG1269A , 38-50 nM ALK1151Tins , 77-113 nM ALKG1202R , respectively.

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