Lorlatinib (Standard)

Description

Lorlatinib Standard is the analytical standard of Lorlatinib. This product is intended for research and analytical applications. Lorlatinib PF-06463922 is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of 0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM ALKL1196 , 14-80 nM ALKG1269A , 38-50 nM ALK1151Tins , 77-113 nM ALKG1202R , respectively.