GENERAL CATALOGUE
Losartan-d4 (carboxylic acid)
HY-12765S · 1 mg
MedChemExpress · Cat: HY-12765S
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Catalog No: HY-12765S
CAS No: 1246820-62-1
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
Losartan-d4 carboxylic acid E-3174-d4 is the deuterium labeled Losartan Carboxylic Acid HY-12765 . Losartan Carboxylic Acid E-3174 , an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 AT1 antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells VSMC . Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
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