LRRK2-Knockout Microglia Cell Line

Description

This microglia cell line features a stable knockout of leucine-rich repeat kinase 2 LRRK2 . Mutations in LRRK2 are the major genetic cause of autosomal-dominantly inherited Parkinsons disease.This modification allows for in-depth studies on LRRK2s functions within microglia, the brains resident immune cells, and its impact on neuroinflammation and neuronal signaling. Utilized primarily in neurodegenerative research, this cell line facilitates exploration of LRRK2s involvement in microglial activation, cytokine production, and phagocytic activities, providing insights into the mechanisms that potentially contribute to disease progression. It serves as a crucial tool for developing therapeutic strategies targeting microglial functions in Parkinsons disease and for broader applications in studying the molecular underpinnings of neuroinflammation and immune responses in the central nervous system. Note: this product is exclusively available for sale to end users located in China. For inquiries, please contact: B14212009 Tel: 0511-83367989 Fax: 0511 8336-7989 Email: order.china@abmGood.com