

HY-162729 · 50 mg
MedChemExpress · Cat: HY-162729
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medchemexpress.com/lsd1-in-34.htmlDescription
LSD1-IN-34 Compound 7d is the orally active inhibitor for Lysine-specific demethylase LSD and monoamine oxidase MAO , with IC50 of 4.51 and 18.46 nM, for LSD1 and MAO A. LSD1-IN-34 inhibits the Ang II-induced neonatal rat myocardial fibroblasts NRCFs activation, without significant toxicity 20 ?M . LSD1-IN-34 inhibits TGF?/Smad signaling pathway, and ameliorates heart failure in mice. LSD1-IN-34 exhibits good pharmacokinetic characteristics in rats.







