LSD1-IN-38

Description

LSD1-IN-38 Compound 23e is a reversible, orally active inhibitor for lysine specific demethylase 1 LSD1 with an IC50 of 1.2 nM. LSD1-IN-38 inhibits the proliferation of cancer cells MV4-11, Kasumi-1 and NCI-H526, with IC50 of 5, 4 and 11 nM, respectively. LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 ?M, and induces differentiation in MV4?11 cell. LSD1-IN-38 exhibits antitumor efficacy in mouse models.