Luc-Akt-PH/YFP Stable MCF-7/B2 Stable Cell Line

Description

Luc-Akt-PH/YFP Stable MCF-7/B2 Stable Cell Line express the pleckstrin homology PH domain of Akt fused to Renilla luciferase with a YFP-Mem, allowing the ability to monitor the PIP3 production in real time through the established BRET biosensor pair. In which the Luc-Akt-PH will be recruited to the plasma membrane due to PIP3 production which then results in an energy transfer between the luciferase and YFP. The cells are suitable for the screening and study of molecules on the PI3K/Akt pathway for diabetes and cancer-related research. This cell line is the can be used with the Luc-Akt-PH Stable MCF7 Cell Line available at abm, Cat. T3160 for experimental studies.