GENERAL CATALOGUE
LUNA18
HY-156002 · 1 mg
MedChemExpress · Cat: HY-156002
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medchemexpress.com/luna18.html
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Catalog No: HY-156002
CAS No: 2676177-63-0
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor. LUNA18 phosphorylates ERK and AKT and decreases cell proliferation in RAS-mutated cancer cells. LUNA18 exhibits RAS signal inhibition and potent anti-cancer activities through inhibiting interaction between RAS and guanine nucleotide exchange factors GEFs in a mouse xenograft model. LUNA18 shows significant cellular efficacy against cell lines with KRAS genetic alterations, such as colon cancer, stomach cancer, non-small cell lung cancer and pancreaticcancer.
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