LY 341495, Group II antagonist

Description

MW 353.4 Da, Purity >98 %. Water-soluble and very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Disodium salt of LY 341495 ab120199 which displays Kd values of 1.67 human mGlu2 , 0.75 mGlu3 , 31.6 mGlu6 , 72.7 mGlu7a and 14 human mGlu8a receptors nM. LY 341495 displays IC50 values of 7.8, 8.2 and 22 muM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. It is readily brain penetrant and active in vivo. Also available in simple stock solutions ab144500 - add 1 ml of water to get an exact, ready-to-use concentration.