GENERAL CATALOGUE
LY2183240
HY-10865 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-10865
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Catalog No: HY-10865
CAS No: 874902-19-9
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
LY2183240 is a highly potent blocker of anandamide uptake IC50= 270 pM; Ki=540 nM . LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase FAAH with an IC50 of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzymes serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC50s of 5.3, 0.09, 8.2 nM for MAG lipase, bh6 and KIAA1363, respectively .
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