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LY3522348
GENERAL CATALOGUE

LY3522348

HY-149987 · Free Sample (0.1 - 0.2 mg)

MedChemExpress · Cat: HY-149987

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Catalog No: HY-149987
CAS No: 2568608-48-8
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress

Description

KHK-IN-3 Example 1 is a ketohexokinase KHK inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis NASH , diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate FIP at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation.

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