Lysosomal P-gp targeted agent 1

Description

Lysosomal P-gp targeted agent 1 Compound 14 is an anti-tumor agent targeting lysosomal P-glycoprotein Pgp . Lysosomal P-gp targeted agent 1 is selectively transported into lysosomes by overexpressed Pgp, release nitric oxide NO to generate reactive oxygen species ROS , resulting in lysosomal membrane permeabilization LMP and inducing apoptosis. Lysosomal P-gp targeted agent 1 can overcome P-glycoprotein-mediated drug resistance and lead to cell cycle arrest, but relatively low toxicity to normal cells. Lysosomal P-gp targeted agent 1 has antitumor activity, significantly inhibits tumor volume.