MA191

Description

MA191 is a FLT3 PROTAC degrader. MA191 abrogates FLT3 inhibitor resistance from rebound activation of mitogen-activated kinases. MA191 mediates rapid FLT3-ITD degradation through a mechanism requiring VHL, neddylation, and BIM. MA191 reduces FLT3-ITD levels before inducing apoptosis. MA191 halts AML cell proliferation in Danio rerio. MA191 can be used for the study of acute myeloid leukemia AML Pink: FLT3 ligand: HY-175311 , Blue: E3 ligase CRBN Ligand HY-112078 , Black: Linker, E3 ligase ligand-linker conjugate HY-175312 .